Endocrine Abstracts

Cognitive dysfunctions, observed in the course of thyroid diseases (hyper- and hypothyroidism), have – in the recent years – been the subject of interest for many research teams. Even mild disorders of thyroid functionality are associated with hormone concentration changes which affect the general mood and cognitive functions. The efficiency of cognitive functions, which allow the man’s adaptation to environment al conditions, is determined by the activities of ...

Objective: Previous studies indicated that two glucocorticoid receptor gene polimorphisms bclI and N363S (GC-S) are associated with increased sensitivity to glucocorticoids and two other polymorphisms 9β and ER22/23EK (GC-I) are related to decreased sensitivity to glucocorticoids. The aim of the study was to determine whether these genetic changes can effect on the occurence of steroid-induced adverse events.Methods: One hundred and fifty p...